Antifungal efficacy against different strains of Candida spp. Drug release profile and ex vivo vaginal permeation studies were performed. The formulations were physically, mechanically and morphologically characterized. CTS was used by its mucoadhesive properties and P407 was used to exploit potential advantages related to increasing drug concentration in order to provide a local effect. The present study was designed to develop and characterize three hydrogels of chitosan (CTS), Poloxamer 407 (P407) and a combination of both containing 2% caspofungin (CSP) for the vaginal treatment of VVC. Although most patients respond to topical treatment, there is still a need for increase the therapeutic arsenal due to resistances to anti-infective agents. It is manifested as changes in vaginal discharge, irritation, itching and stinging sensation. Vulvovaginal candidiasis (VVC) poses a significant problem worldwide affecting women from all strata of society. The method is highly flexible in terms of barrier composition, choice of probes and membrane active compounds. Proof-of-principle is presented that WIND-PVPA can be used to evaluate the lipid barrier destabilizing effect of active guest molecules by measuring changes in passive water- and ion permeabilities upon exposure. The results obtained are compared with explicit molecular dynamics simulations of lipid bilayers, AMPs, water and salt, where the motions of all individual water molecules relative to the lipid bilayer are monitored over the course of the simulations, allowing the calculation of theoretical apparent permeability constants of the corresponding single bilayer systems. WIND-PVPA is demonstrated using four anti-microbial peptides, to show that membrane active molecules can be differentiated by their disruptive influence on the PVPA system. NMR spectroscopy is used to quantify the water directly (D2O) and the ions indirectly (complexed with EDTA) as a function of time. The apparent permeability constants of water- and ions across the PVPA barriers are determined in a one-pot experiment under the influence of membrane-active guest molecules. But there’s scant evidence to support that it works, making vabbing one of the many TikTok attraction hacks that doesn’t really have any basis in fact at all.Water/Ion NMR Detected – Phospholipid Vesicle Permeability Assay (WIND-PVPA), is presented as a novel, straightforward and automatable method to assess lipid barrier integrity in vitro. Could it potentially hurt your chances to get a date at the bar or the gym? Unless you specifically tell them that you’ve been vabbing, probably not. One 2012 review of such studies on pheromones, for instance, found that “although there are studies to support this phenomenon, they are weak, because they were not controlled others have proposed that human olfactory communication is able to perceive certain pheromones that may play a role in behavioral as well as reproductive biology.” But many scientists are critical of the sweaty T-shirt study, as well as the general idea that odor plays any role whatsoever in sexual attraction in general. Since the sweaty T-shirt study, there have been many DNA-matching dating startups and sweaty T-shirt parties based on Wedekind’s results and built around the idea that people can determine genetic compatibility by odor. The women overwhelmingly said they preferred the ones that had a different MHC (major histocompatibility) gene profile than their own, which is said to determine genetic compatibility with a potential mate. There is, for example, a famous Swiss study from 1995 colloquially known as the sweaty T-shirt study, in which biological researcher Claus Wedekind gave female college students men’s sweaty T-shirts and asked which they preferred by the smell. T here has, however, been research conducted on whether the scent of pheromones play a role in sexual attraction, and while most of these studies have been done on animals, there have been studies done with humans that are not exactly conclusive. Of course the research community has not prioritized studies on whether or not using vaginal fluids as perfume attracts sexual partners, so there’s very little data to support whether vabbing itself works. In one viral video with more than four million views, creator appears to try it at the gym for the first time, saying, “You guys aren’t gonna believe me, but now I’m in the sauna and it worked - the vabbing worked,” later explaining in a follow-up video she was approached by a man for her number while doing lunges on the treadmill. Despite going mildly viral in 2019, vabbing recently started taking off in earnest on TikTok, where creators are either expressing disgust at the prospect of using their own vaginal fluids as perfume or trying it out themselves.
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